Pathway Group Lasso for Integrating Metabolomics and Transcriptomics
نویسندگان
چکیده
INTRODUCTION: Transcriptomics and metabolomics are high-throughput technologies that are critical to contemporary biomedical sciences, measuring gene expression levels and metabolite concentrations, respectively. Effective methods of integrating metabolomics and transcriptomics data are highly desired. Gene and metabolic pathways represent accumulated expert knowledge in particular domains. LASSO regression is widely used for feature selection, and group LASSO incorporates prior knowledge of groups of variables.
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